Insulin’s Role in Life Long Good Health




As Americans battle the bulge we are also serious about anti-aging. We spend billions of dollars on skincare, cosmeceuticals and other anti-aging products. According to a report by Market Research by 2010 spending for cosmeceuticals is expected to surpass $17.2 billion. However a recent research study reports that the secret to staying young is not in our medicine cabinet but in good old diet and exercise.


A study led by Dr. Morris White, a Howard Hughes Medical Institute Investigator at Children s Hospital in Boston demonstrated that diet and exercise might keep you young by reducing the action of insulin in the brain.



It s no secret that diet and exercise are good for our health

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but this study validated why we should exercise and refrain from overeating. Dr. White and team examined the entire series of actions in the cell that control the body s use of insulin known as the insulin pathway. Insulin signals our body that we re well fed. Without insulin you could eat a large amount of food but be in a starvation state because without insulin your body cannot access the calories that are in the glucose. Fasting and exercise causes our cells to be more sensitive to insulin.


Dr. White and his team used engineered mice without working copies of Irs2 (a gene involved in the insulin pathway). They found that mice who had

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no copies of Irs2 had defective brains and diabetes while mice with one working copy lived 18 percent longer than normal mice. Insulin turns on Irs2 in the brain so when there s lower Irs2 activity the mice had a longer life span.


When you control your weight with a healthy diet and exercise you keep your peripheral tissues sensitive to insulin and your body has to make less of it, and that adds up to longer life. The great news is that your daily walk in the park not only helps your waistline but may just add up to a few more years of life, and a few more dollars in your wallet!


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